Arachidonate Metabolism in Obese Zucker Rat Kidney : Reversal by Angiotensin II Upregulation of Angiotensin II Type 1 Receptor, Inflammatory Mediators, and Enzymes
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چکیده
Zhong-Gao Xu, Linda Lanting, Nosratola D. Vaziri, Zhen Li, Lili Sepassi, Bernardo Type 1 Receptor Blockade of Arachidonate Metabolism in Obese Zucker Rat Kidney : Reversal by Angiotensin II Upregulation of Angiotensin II Type 1 Receptor, Inflammatory Mediators, and Enzymes Print ISSN: 0009-7322. Online ISSN: 1524-4539 Copyright © 2005 American Heart Association, Inc. All rights reserved. is published by the American Heart Association, 7272 Greenville Avenue, Dallas, TX 75231 Circulation doi: 10.1161/01.CIR.0000161831.07637.63 2005;111:1962-1969 Circulation. http://circ.ahajournals.org/content/111/15/1962 World Wide Web at: The online version of this article, along with updated information and services, is located on the
منابع مشابه
Upregulation of angiotensin II type 1 receptor, inflammatory mediators, and enzymes of arachidonate metabolism in obese Zucker rat kidney: reversal by angiotensin II type 1 receptor blockade.
BACKGROUND Severe obesity can result in proteinuria and progressive glomerulosclerosis in humans and experimental animals. The associated renal disease is ameliorated by weight reduction and/or blockade of the renin-angiotensin system. Various growth factors, cytokines, and lipid mediators are implicated in the pathogenesis of renal disease. To explore the possible involvement of these mediator...
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Recently, there has been a growing interest in studying the role of angiotensin II type-2 (AT(2)) receptor in renal/cardiovascular function in pathological conditions. The present study was designed to determine the functional role of the AT(2) receptors on natriuresis/diuresis and compare the level of the tubular AT(2) receptor expression in obese and lean Zucker rats (12 weeks old). Under ane...
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